Brain Metastases in breast cancer

The informational material on brain metastases in breast cancer was developed through a collaboration between ABC Global Alliance and Seagen.

Learn more about brain metastases

The brain is the most complex organ in the body.1 It is protected by the blood-brain barrier, which acts like a gatekeeper for the brain.2 Although the blood-brain barrier is effective, it’s not impenetrable.3
Sometimes cancer cells break away from their original tumour to a new area of the body, including the brain.4 Nearly 1 in 3 people with metastatic breast cancer eventually develop brain metastases5 - learn more about how they develop, how to recognise them, and when to speak to your doctor or nurse.

References:

  1. National Institute of Neurological Disorders and Stroke. Brain basics: Know your brain. Available at https://www.ninds.nih.gov/healthinformation/public-education/brain-basics/brain-basics-know-your-brain [Accessed October 2023]
  2. Daneman R, Prat A. Cold Spring Harb Perspect Biol.2015;7(1):a020412
  3. Kadry H, et al. Fluids Barriers CNS. 2020;17(1):69
  4. Cancer.Net. Breast cancer - metastatic: introduction. Available at https://www.cancer.net/cancer-types/breast-cancer-metastatic/introduction [Accessed October 2023]
  5. Zimmer AS, et al. Cancer Rep (Hoboken). 2022;5(4):e1274.

Why do brain metastases happen?

Learn About:

  • The functioning of the brain and the blood-brain barrier
  • Recognizing potential symptoms of brain metastases
  • Future implications
  • Causes of brain metastases
  • Methods of diagnosing brain metastases

Why are brain metastases harder to treat than other metastases?

  • Why it is harder to treat metastases in the brain than in other parts of the body?
  • What needs to be considered when treating brain metastases?
  • How are symptoms of brain metastases treated?
  • How brain metastases are treated?
  • What does the future hold?